Why Pashiin

Learn about how Pashiin combats the stress that causes low sexual performance and how Pashiin is improving the landscape of sexual wellness for the world.

In the US, over 80 million people suffer from sexual dysfunction.

Sexual Health & Neurotransmitters

How stress is affecting neurotransmitter levels lowering sexual peformance for millions of people.

With the ever increasing stress of our society, we unintentionally carry that stress with us into the bedroom. This can have many disastrous effects on sexual health and mental health. For example, anxiety keeps our libido down and us from connecting, stagnation in the blood caused by stress lowers sexual performance, pharmaceutical and alcohol use damage the sex related organs, low self-esteem keeps one from being in a relaxed state, and many other complex factors contribute to poor sexual health. The result is low sexual performance from lower levels of love-neurotransmitters being expressed.


Happiness and well-being


Pleasure and satisfaction


Connectin and bonding


Flow state-and motivation

The Current Solutions

Why the current solutions that people are using to improve their sexual performance aren't enhancing anything.


Sexual Enhancement Supplements

We have indexed over 300 similar (multi-ingredient) products for sexual enhancement and have found that none of them included significant amount of the active ingredients. This is why most (over 100 in a study of 150 sampled) manufacturers of sexual enhancement supplements will actually hide illegal drugs in their products. Whereas PASHIIN™ is made of the highest purity of clinically effective dosages of ingredients with the certifications to back this claim. Not only that, PASHIIN™ is the only product to date that targets both the mind and body to deliver a better overall experience.


Alcohol weakens the liver and kidneys which lower sexual performance, and ruins memory, and spiritual awareness. Over time, these things will not only cause someone to lose their sexual health, but their mental health too. Furthermore, because PASHIIN™ is not intoxicating nor does it contain caffeine, one can take PASHIIN™ in the morning before work, or at night before bed without disturbed sleep.


Aren’t we tired of shaming sex as if it were something dirty when it can be one of the most fundamental and pure acts of the human experience? Too often we see marketing companies taking advantage of this to sell you a new cologne, some “penis pills”, or just about anything that can be sold. But bastardizing the image of sex, or shaming sex is creating unhealthy and often critical self-views and is one of the fundamental reasons for the mental health epidemic across the world. No longer do we have to feel awkward or ashamed about taking care of our sexual health. Let’s take a holistic, scientific, and common sense approach to solving one of life’s greatest challenges. For the mastery of sex is not in any detail of the performance as it is portrayed in the cinema, but rather the mental, emotional, and spiritual value it is bringing you, your health, and potentially your family.

5 Elements of an effective solution

In order to best understand what makes a sexual health products effective, it's best to first understand how to create a sexually healthy state.

Stress Reduction

The primary signaling hormones for stress are cortisol and adrenaline. For the sake of brevity, know that adrenaline and cortisol seem to be have similar effects when it comes to sexual health, so it is safe to assume, that neither of these two hormones are useful in the bedroom. Cortisol is a type of glucocorticoid that is released by the zona fasciculate of the adrenal cortex. [source] People who have higher than usual cortisol levels (which can happen after work, drinking caffeine, or even just hectic daily life) experience deficiencies in multiple areas of sexual health [source]. Furthermore, high cortisol levels are associated with a decrease in sex hormones such as testosterone and estrogen. [source] If the mind and body are stressed, tense, and inflexible, then it becomes nearly impossible to increase pleasure and happiness related neurotransmitters such as serotonin and dopamine as there is an inverse relationship between these groups. [source] As you will see in the following steps, lowering cortisol and adrenaline levels must be done before physiological sexual enhancement can take place.

Rebalance Sex Hormones

Now that we got our stress levels under control, the next most important thing is to rebalance sex related hormones. [source] We are referring to primarily testosterone and estrogen. Kessipeptin (a neuropeptide that acts upstream of gonadotropin-releasing hormone (GnRH) neurons) is also a major signaling molecule of the reproductive system. [source] Some common reasons why we might experience lower than normal levels of our sex hormones are hypersexuality, stress, alcohol use, drug use (including caffeine and nicotine), and many pharmaceuticals are known to have a negative effect on hormone production. [source] To improve the production and rebalance the sex hormones, we must equip the metabolic pathway used to create them. Then one’s sex drive can be restored.

Enhanced Blood Flow

When it comes to physical stimulation for both men and women, and erectile function for men, blood flow can be a factor that will “make it or break it”. Stress on the cardiovascular system causes constricted blood vessels and high blood pressure. [source] When the blood is unable to flow to the genitalia, it can cause difficulty orgasming and / or getting an erection. [source] To counteract this, scientists have found that phosphodiesterase-5 (PDE5) inhibitors work especially well to open capillaries and increase blood flow in the genital areas. The most notable is sildenafil citrate (Viagra) which was developed and based the herb from Traditional Chinese Medicine called Epimedium (Xian Ling Pi). When a PDE5 is combined with other blood flow enhancing agents, (although not as strong as the PDE5s), the whole body will experience increased blood flow, relaxation of the muscles, and heightened physical sensuality.

Uplift Mood

That mood is established by neurotransmitters related to your reward pathway. When the mind feels relaxed, safe, and comfortable, serotonin is released making us feel a bit more joyful. [source] When we feel attracted to our partner, dopamine is released by the hypothalamus to signal the reward complex that our motivations will bring about pleasure. [source] Oxytocin is released at very specific events, mostly related to the climatic parts of the sexual experience. [source] Now the release of these neurotransmitters is a two way street. One can think sexual or positive thoughts to increase neurotransmitter release, or one can increase the release of neurotransmitters to increase positive sexual thoughts. Considering that we just got through the stress of the day and are still lowering our cortisol levels, it would make most sense to uplift the neurotransmitter levels first, then use that as a catalyst to create a cycle where one can think more passionately, which then again releases more mood elevating neurotransmitters. This will become a cycle of passion that will leave both people laughing, sensual, relaxed, and passionate.

Elevate Awareness

Now here is where things get a bit more advanced, and also where we are able to take an ordinary experience to the extraordinary. By elevating one’s awareness, one will function at a higher state of consciousness. In this state, flow-state is easier to achieve, emotional intelligence increases, it becomes easier to share ideas and feelings from a deeper part of one’s being, and everything will seemingly flow naturally without effort. This is often why people drink alcohol, is for this altered mindstate, emotional connection, and a ease and flow to things. The main difference between alcohol and what we are describing is that alcohol comes with the cost of awareness in many categories for increased emotional awareness, whereas what we are describing here is awareness on all levels without the sacrifice of anything except for maybe boredom. To achieve this state, the mind uses acetylcholine to process information more fluidly and naturally, thus increasing our mental capacity and how much sensory information we can process. [source] GABA is used to lower activity of parts of our brain such as the prefrontal cortex that tend to cause things such as pensiveness, overthinking and judging, allowing for more self expression and creative thinking. [source] And norepinephrine is a signaling molecule that is used in heightened activity that makes us concentrate intensely, and brings us to the present moment. [source] Together, these 3 neurotransmitters will create a mindshift that will put you and your loved one on spiritual level where anything is possible.

An Ultimately Effective Solution

See a breakdown of the ingredients in PASHIIN™ by category of how we solved each of the requirements to create the world’s most effective solution.
Nootriplex™Powerful cannabinoids promote relaxation via the endocannabinoid system, boosting the immune system, improving liver metabolism, and relaxing fascia.[1]AshwagandhaAshwagandha has been shown in multiple studies to reduce cortisol and other stress biomarkers. [2] Furthermore it has been used in ancient Ayurvedic medical practices to reduce stress and promote sexual well-being for thousands of years.[3]Rhodiola RoseaRhodiola rosea contains salidroside which is a monoamine oxidase inhibitor (MAOI). These slow the breakdown of monoamine neurotransmitters such as serotonin and dopamine to promote the relaxing effects.[4]FluorobutFluorobut increases GABA levels which help regulate pre-synaptic and post-synaptic activity in the central nervous system, as well as the enteric, cardiac, and hepatic nervous systems.[5]AniracetamAniracetam is known to produce anxiolytic (stress reducing) effects through the NMDA receptor complex. [6]MacaWhere the exact mechanism of action is not known, it is known that Maca reduces stress on the hypothalamic-pituitary-adrenal axis which reduces stress hormone levels. [7]Macuna PruriensMacuna contains L-Dopa which is a precursor to dopamine. By supplementing with L-dopa, dopamine levels can be raised promoting increased feelings of relaxation and pleasure. [8]KavaThe pharmacological properties of kava are postulated to include enhanced GABAa receptor activity, reduced adrenaline levels, and to act as an MAOb inhibitor. [9] Each of these mechanisms promote icreased relaxation.DamianaDamiana reduced stress due to its anxiolytic properties. [10]


Zinc has been shown to alleviate symptoms of erectile dysfunction, premature ejaculation, and lack of production of sex hormones as well as many other sexual health disorders. Zinc supplementation can improve sexual health and reduce the likelihood of any issues. [11] [12] [13]


Ashwagandha has been shown to reestablish balanced sex hormone levels. [14]


dehydroepiandrosterone (DHEA) is a a building block that your body uses to produce sex hormones. By supplying this ingredient, your body will have an easier time balancing hormone levels and returning natural sex drive and other sexual health benefits. [15]


Multiple of the B-vitamin series specifically folic acid, pantothenic acid, and pyrodoxine HCL are involved in critical metabolic pathways for hormone production. By making sure that there is enough of these substances, one can be sure that the body will be able to produce ample amounts of the sex hormones. [16] [17] [18

Red Panax Ginseng

Where red panax ginseng did not increase testosterone levels, it does seem to have other secondary effects on improving sexual health, exercise performance, and vitality. [19]

Cordyceps Sinensis

Cordyceps is known to boost testosterone levels in men and estradiol (a very important signaling hormone for sexual and reproductive health) levels in both men and women. [20]


Cannabinoids have been shown in studies to improve cerebral and peripheral blood flow, thus enhancing mental capabilities and physical. [21]


Epimedium contains a compound called icariin. Icariin is what the drug sildenafil citrate (Viagra) was developed from although it is completely plant based and natural for the human body. It is in the class of substances called PDE5 inhibitors which are known for their ability to increase penile and vaginal blood flow. [22] Enhanced blood flow to these areas can help with erections and stimulation.

Cordyceps Sinensis

Cordyceps improves the oxygenation of the blood and overall heart health which leads to greater blood potency. [23] [24]


Ashwagandha has been shown to increase blood potency (oxygen, nutrient deliver) and even red blood cell count. [20] The strengthening of the blood allows for improved sexual performance.


Damiana is often used in medicine to improve sexual health as it is an aphrodisiac and has been shown to improve the health of the reproductive organs and increase blood flow. [25] [26]

Rhodiola Rosea

Because Rhodiola contains salidroside (MAOb inhibitor) monoamines such as serotonin and dopamine will be increased, giving the experience of a better mood. [27] Especially with the rosavarin, which is an MAOb inhibitor, serotonin levels will greatly increase giving an even hightened sense of happiness and a reduced feeling of worry or fear. [28]


Multiple studies have shown kava to promote feelings of cheerfulness, happiness, and an oveall sense of well-being. [23]


Phenylethylamine (PEA) itself is a neurotransmitter. So by consuming it, one is increasing PEA levels temporarily. PEA is associated with the feelings of happiness, pleasure, and emotional well-being. [29]


Can-nabinoids have long been used to improve mood, both medically and recreationally. There is a substantial amount of evidence for this. [30]

Macuna Pruriens

One of the constituents of Macuna Pruriens is L-dopa, a precursor to dopamine. By consuming Macuna, dopamine levels go up signaling the reward pathway in the brain, and elevating one’s mood. [31]


Damiana acts as an MAOa inhibitor and further improves mood through increasing synaptic dopamine, serotonin and other monoamine levels. [32]


Aniracetam enhances dopamine and serotonin release in the prefrontal cortex mainly by facilitating the action of N-anisoyl-GABA on nicotinic acetylcholine receptors. Activation of the cholinergic system improves cognitive function and brain health. [33] Acetylcholine is used by neurons to signal the formation, and reconstruction of neuronal junctions (cellular process of learning, cognitive procession, and memory formation,  consolidation, and recall).

Aniracetam is also known to enhance cerebral blood flow and activity in the area of the brain that is responsible for collective and holistic thinking. [34]

These two factors also lead to improved attention span and an easier transition to flow state.

Fluorobut is known to be anxiolytic and enhance cognition. Most notably, it also has been shown to improve social intelligence which works well when communicating deeply and openly with a partner. [35] Furthermore it is known to have euphoric effects which can improve sexual and exercise performance. [36]


Phenethylamine reacts with the TAAR-1 receptors and causes a release in neurotransmitters. These neurotransmitters affect mood, mental sharpness, awareness, and well-being. [37]

Red Panax GinsengRed Panax Ginseng has been shown to reduce neuroinflammation and help with brain repair. [38]Cordyceps SinensisLowers brain irritation and improves circulation of the neurovasculature. [39] [40]NootriplexCannabinoids have been shown in studies to help with a number of issues related to cognitive decline. [41] [42] [43]Rhodiola RoseaHelps reduce aging by reducing oxidative stress. [44]AniracetamHelps maintain mental acuity and reduces likelihood of cognitive related issues. [45]FluorobutProtects the brain via increased circulation, immune response, and reducing stress. [46] [47] [48]MacaEnhanced neuroprotection and preservation of memory. [49] [50]AshwagandhaImproves stress tolerance and helps reduce the likelihood of a number of mental health issues. [51] [ [52] [53] [54]

What people say about sexual satisfaction

"96% of respondents said being emotionally connected results in the best sex."

Not only does PASHIIN™ beat out the alternatives at their own strengths, but it is also more affordable, and it is the only product that focuses on the neurological aspects that allow you to create more meaningful experiences.

Improve Sexual Health

Reduce stress. Enhance flow. Improve performance.

People can get anxious when it comes to sexual situations for many reasons such as: concern about sexual performance, body image issues, stress about physical conditions that can affect sexual satisfaction, relationship issues, such as a lack of emotional connection, stress from other areas of life, or general nervousness. When you feel anxious, your body releases powerful stress hormones such as epinephrine (also called adrenaline) and cortisol. These hormones constrict blood vessels, reducing blood flow to parts of your body. Caffeine also releases these hormones so it is particularly useful to avoid during sexual intercourse.

Performance anxiety makes it much more difficult to maintain the mood, keep the blood flowing to the right parts, and enjoy the sex with your partner. Over time, performance anxiety can have a significant negative effect on an individual’s sex life, often resulting in a reduced level of interest in sexual activity. PASHIIN™ works to reduce stress as it’s first mode of action to keep you from feeling this way and to keep you focused on what matters most.

Reduce Stress and Feel Better

8 of the most powerful stress reducing substances that improve sexual performance and sexual health.

Macuna Pruriens

Used in Ayurvedic medicine since 1500 BC for revitalize reproductive systems, re-establish sex hormone balance, and improve mental clarity.


Reduces stress related hormones such as cortisol, boosts testosterone, and has been shown in studies to improve sexual health, especially in women.

Rhodiola Rosea

An adaptogenic herb from Scandinavia historically used for increasing energy levels, improving mood, and increasing fertility.


A very powerful nootropic designed for heightened mood and relaxation. It increases GABA similarly to alcohol without the lack of coordination or judgement.


A powerful engineered phytocan-nabinoid compound designed for optimal healing and relaxation developed by Nootripure.

Piper Methysticum

Also known as Kava, this herb is especially famous for its potent relaxing effects said to be similar to alcohol, yet delivers many other benefits for improving mental health.

Peruvian Ginseng

This herb is mostly used for sexual health purposes as it has been taken by the Peruvians for thousands of years for fertility, but it still has potent calming and mood lifting effects as well.


A nootropic from the racetam family. Like other racetams, it can produce heightened awareness and verbal communication skills, but aniracetam is also particularly known for its powerful anxiolytic effects.

Pashiin includes each of these ingredients at scientifically backed and effective dosages. You can view more about these ingredients and all the others on the Ingredient Page.

Now you can enhance your sexual performance so that you can live fully once again thanks to our team of scientists.

Wendy Small

Dr. Wendy M. Yoder Ph.D


PASHIIN™ Project Lead

“The objective is to improve emotional intimacy by restoring many of the neurochemical imbalances responsible for generating the psychological experience of love.”

We depend on you resolving your sexual health issues.

Nootripure is a neuroscience based non-profit for mental health whose mission it is to give people tools to better their mental well-being. If our research and technology doesn’t give results, then we don’t get funded and go out of business. The Nootripure products are an essential part of what we do because it proves the validity of our research and technology and allows us to track our impact. As we continue to develop technology, we hope that we can use our data to expedite our research to provide better solutions that heal more people, faster.

Or learn more about the benefits of Pashiin here.